Tweaking... Where to begin

I, up to this point, have been a plug and play type of guy. I know that am missing some of the more fruitful stuff that I can do on a Fantom. SO, for a rookie, tweaking, where (as to what parameter) do someone usually begin with. If some one could show me how to begin with an initialized patch, I probably could teach myself a lot from there. Thank All of You. I know I will be up and tweaking in no time at all.


Chris
It all started in D-50's