The lack of 64 bit support, in my case, was a minor annoyance. The G's internal data storage can still be recognised in Vista (at least) as a mass storage device if the 'computer' USB connector is plugged into your computer, despite no drivers being present - so that's good for importing information. You can still copy projects in and out in this way, and then open them in the separate librarian on your computer for messing with later. It's nothing that can't be done (more slowly) with a USB stick, anyway.
The editor still functions through 'Sysex' messages transmitted by any MIDI interface - so buying an UM-1EX midi adapter will allow you to overcome this problem with no worries. There are drivers available from Roland for this particular piece of hardware, and it's a cinch to get up and running. You'll also obviously have the ability to now transmit MIDI from the G.
What you will lack is the ability to use the G in your DAW for input/output via the USB audio facility. This can be overcome by purchasing any number of separate interfaces (sound cards etc.) - and seeing as how the usb audio would ordinary give you 2 channels (stereo), you can use a simple digital out coaxial to replicate it. If you're only going to be using the G, you can get something relatively cheap as you won't be converting an analog signal.
Most musicians who use a computer probably already have, or should consider, investing in this sort of hardware in order to expand their options in the studio. If you plan on processing the sound from the G with external effects, you'll probably be wanting to make use of as many different outputs as possible in order to overcome the G's 'limitations'. In that case, something (expensive) with good converters is essential. That said, if you can stand it, you can still record each 'track' separately in your DAW and process that if you want. All you need is one output of 2 channel stereo.
Finally, the last problem is a lack of 64 bit functionality for the actual editor software itself. While the standalone program will run in a 64 bit environment like Vista as an emulated 32 bit process, in a 64 bit DAW such as Cubase, you'll encounter problems with the VST. All this means in practical terms is that you'll have to run the editor outside of the program. That's it.
It's definitely worth making the jump to 64-bit if you plan on using sample-heavy VSTs that require lots of RAM. You'll still need plenty of CPU horsepower, though. REVerence, Cubase 5's flagship reverb insert, is a hungry little beast.
